Look at his loss, make it your gain

I read the article, "Look at his loss, make it your gain," by Diane Flacks. She interviews John Kach about his experience with bacterial menigitis. John contracted bacterial menigitis type C when he was a freshman in college. This caused John to go into a coma for six weeks and eventaully the loss of a few fingers and his leg. The doctors thought he would have severe brain damage, but he survived and has now found his purpose in life.
The author wrote "Kach knows it's only luck that spared his life, which makes him determined to use that life well. "This happened to me. I'll take one for the team, that's fine. But now I have to try and prevent others from having to go through what I and my family did. I lived for a reason. I shouldn't be here. I have to try to help other people."
John is now doing everything is his power to help promote the menigitis vaccine. It's so amazing that he's willing to take his trials and turn them to help others. He's already doing a lot of good things- meningitis vaccines are now required (or a waiver can be signed) for incoming college freshman in 24 states. For more information, click here

John Kach

Could vaccines be a solution to cancer?

Check out this article! The University of Pittsburgh School of Medicine is working on a vaccine to prevent colon cancer. Wouldn't that be amazing if we could prevent this third leading cause of death? Scientists are making great strides with vaccines.

Vaccine To Prevent Colon Cancer Being Tested In Patients
ScienceDaily (Mar. 19, 2009) —

Researchers at the University of Pittsburgh School of Medicine have begun testing a vaccine that might be able to prevent colon cancer in people at high risk for developing the disease. If shown to be effective, it might spare patients the risk and inconvenience of repeated invasive surveillance tests, such as colonoscopy, that are now necessary to spot and remove precancerous polyps.

Colon cancer takes years to develop and typically starts with a polyp, which is a benign but abnormal growth in the intestinal lining, explained principal investigator Robert E. Schoen, M.D., M.P.H., professor of medicine and epidemiology at the University of Pittsburgh. Polyps that could become cancerous are called adenomas.

In a novel approach for cancer prevention, the Pitt vaccine is directed against an abnormal variant of a self-made cell protein called MUC1, which is altered and produced in excess in advanced adenomas and cancer. Vaccines currently in use to prevent cancer work via a different mechanism, specifically by blocking infection with viruses that are linked with cancer. For example, Gardasil protects against human papilloma virus associated with cervical cancer and hepatitis B vaccine protects against liver cancer.

"By stimulating an immune response against the MUC1 protein in these precancerous growths, we may be able to draw the immune system's fire to attack and destroy the abnormal cells," Dr. Schoen said. "That might not only prevent progression to cancer, but even polyp recurrence."
According to co-investigator Olivera Finn, Ph.D., professor and chair of the Department of Immunology at Pitt's School of Medicine, MUC1 vaccines have been tested for safety and immunogenicity in patients with late-stage colon cancer and pancreatic cancer.

"Patients were able to generate an immune response despite their cancer-weakened immune systems," she noted. "Patients with advanced adenomas are otherwise healthy and so they would be expected to generate a stronger immune response. That may be able to stop precancerous lesions from transforming into malignant tumors."

About a dozen people have received the experimental vaccine so far, and the researchers intend to enroll another 50 or so into the study. Participants must be between 40 and 70 years old and have a history of developing adenomas that are deemed advanced, meaning they are greater than or equal to 1 centimeter in size, are typed as villous or tubulovillous, or contain severely dysplastic, or abnormal, cells. After an initial dose of vaccine, the participants will get shots again two and 10 weeks later. Blood samples will be drawn to measure immune response at those time points as well as 12 weeks, 28 weeks and one year later.

People who develop advanced adenomas undergo regular surveillance with colonoscopy so that recurrent polyps, which are common, can be removed before matters get worse, Dr. Schoen said.
"Immunotherapy might be a good alternative to colonoscopy because it is noninvasive and nontoxic," he noted. "And, it could provide long-term protection."

Colorectal cancer is the third leading cause of cancer death in the United States. In 2008, the American Cancer Society estimated that there were more than 108,000 new cases of colon cancer, nearly 41,000 cases of rectal cancer, and almost 50,000 deaths due to both diseases.
Pitt's colon cancer vaccine is sponsored by the National Cancer Institute and The Nathan S. Arenson Fund for Pancreatic Cancer Research. Its adjuvant component, which enhances the immune system's ability to respond to the target protein, was developed and provided by Washington, D.C.-based Oncovir, Inc.

For More information about colon cancer, click here

Are you up to date?

Here is the latest adult vaccine schedule straight from the Center for Disease Control. Check it out and see if you need to make a trip to the doctor be up to date. When we stay current in our vaccines, we can prevent some of the 50,000 deaths per year in adults(see video below)that are caused by vaccine preventable diseases. We all need to do our part!

Shots are for grown-ups, too

This video, from CNN, is a great reminder that vaccinations aren't just for children. We, as adults, need to remember to receive booster shots and still continue to track the vaccinations that have been done. Google had a new application called Google Health. With this program, you can easily track your vaccination records, along with all your medical records. Check it out and see what you think. All you need is a gmail account to use the application.

Autism anti-vaccination fears

I read this article OPINION: Kids Dying Because of Autism Anti-Vaccination Fears by Kevin Leitch. He talked about how the rate of individuals being vaccinated has decreased due to fears of autism. The population becomes vulnerable because of this. This article focused specifically on the increase in cases of whopping cough and the resulting deaths.

In the article, the author stated that, "How terribly sad and tragic that the same situation is playing out across so much of the affluent world – kids dying of vaccine preventable disease – because a few idiots think they know best and are willing to put the lives of others children at risk, when in the third world countries people are still dying by the tens of thousands from vaccine preventable disease and are desperate to get a hold of vaccines."

* I would like to know your thoughts on this issue. How can we make parents aware of the dangers of not being vaccinated, while at the same time dispelling myths?
*For more information, Here's a great article by the CDC.

Super Flu Vaccine

The video is about a possible future "super flu" vaccine that scientists are trying to develop. It's amazing at the strides that are being made and the possibilities for preventing all types of influenza, including H5N1- "avian flu."
source: cbsnews.com

Frequently Asked Questions

As posted on kidshealth.org

What do immunizations do?

Vaccines work by preparing a child's body to fight illness. Each immunization contains either a dead or a weakened germ, or parts of it, that cause a particular disease.
The body practices fighting the disease by making antibodies that recognize specific parts of that germ. This permanent or longstanding response means that if someone is ever exposed to the actual disease, the antibodies are already in place and the body knows how to combat it and the person doesn't get sick. This is called immunity.

Will my child's immune system be weaker by relying on a vaccine?

No, the immune system makes antibodies against a germ, like the chickenpox virus, whether it encounters it naturally or is exposed to it through a vaccine.

Will the immunization give someone the very disease it's supposed to prevent?

This is one of the most common concerns about vaccines. However, it's impossible to get the disease from any vaccine made with dead (killed) bacteria or viruses or just part of the bacteria or virus.
Only those immunizations made from weakened (also called attenuated) live viruses — like the chickenpox (varicella) or measles-mumps-rubella (MMR) vaccine — could possibly make a child develop a mild form of the disease, but it's almost always much less severe than the illness that occurs when a person is infected with the disease-causing virus itself. However, for children with weakened immune systems, such as those being treated for cancer, these vaccines may cause problems.
The risk of disease from vaccination is extremely small. One live virus vaccine that's no longer used in the United States is the oral polio vaccine (OPV). The success of the polio vaccination program has made it possible to replace the live virus vaccine with a killed virus form known as the inactivated polio vaccine (IPV). This change has completely eliminated the possibility of polio disease being caused by immunization in the United States.

Why should I have my child immunized if all the other kids in school are immunized?

It is true that a single child's chance of catching a disease is low if everyone else is immunized. Yet if one person thinks about skipping vaccines, chances are that others are thinking the same thing. And each child who isn't immunized gives these highly contagious diseases one more chance to spread.
This actually happened between 1989 and 1991 when an epidemic of measles broke out in the United States. Lapsing rates of immunization among preschoolers led to a sharp increase in the number of measles cases, deaths, and children with permanent brain damage. Even in 2008, the number of cases of measles in the United States more than doubled from recent years. Most of the cases were among people who had not been vaccinated. Similar outbreaks of whooping cough (pertussis) struck Japan and the United Kingdom in the 1970s after immunization rates declined.
Although vaccination rates are fairly high in the United States, there's no reliable way of knowing if everyone your child comes into contact with has been vaccinated, particularly now that so many people travel to and from other countries. So, the best way to protect your child is through immunization.

Why should I subject my child to a painful shot if vaccines aren't 100% effective?

Few things in medicine work 100% of the time, but vaccines are one of the most effective weapons we have against disease — they work in 85% to 99% of cases. They greatly reduce your child's risk of serious illness (particularly when more and more people use them) and give diseases fewer chances to take hold in a population.
It can be difficult to watch kids get a shot, but the short-term pain is nothing compared with suffering through a potentially deadly bout of diphtheria, pertussis, or measles.

Why do kids who are healthy, active, and eating well need to be immunized?

Vaccinations are intended to help keep healthy kids healthy. Because vaccines work by protecting the body before disease strikes, if you wait until your child gets sick, it will be too late for the vaccine to work. The best time to immunize kids is when they're healthy.

Can immunizations cause a bad reaction in my child?

The most common reactions to vaccines are minor and include:

• redness and swelling where the shot was given
• fever
• soreness at the site where the shot was given

In rare cases, immunizations can trigger more serious problems, such as seizures or severe allergic reactions. If your child has a history of allergies to food or medication, or has had a problem with a vaccine previously, make sure to let the doctor know before any vaccines are given. Every year, millions of kids are safely vaccinated and almost all of them experience no significant side effects.
Meanwhile, research continually improves the safety of immunizations. The American Academy of Pediatrics (AAP) now advises doctors to use a diphtheria, tetanus, and pertussis vaccine that includes only specific parts of the pertussis cell instead of the entire killed cell. This vaccine, called DTaP, has been associated with even fewer side effects.

Why does my child need to be immunized if the disease has been eliminated?

Diseases that are rare or nonexistent in the United States, like measles and polio, still exist in other parts of the world. Doctors continue to vaccinate against them because it's easy to come into contact with illnesses through travel. That includes anyone who may not be properly immunized who's coming into the United States, as well as Americans traveling overseas.
If immunization rates fell, a disease introduced by someone visiting from another country could cause serious damage in an unprotected population. In 1994, polio was brought to Canada from India, but it didn't spread because so many people had been immunized. It's only safe to stop vaccinations for a particular disease when that disease has been eradicated worldwide, as in the case of smallpox.

How long does immunity last after getting a vaccine?

A few vaccines, like the two for measles or the series for hepatitis B, may make you immune for your entire life. Others, like tetanus, last for many years but require periodic shots (boosters) for continued protection against the disease.
The whooping cough (pertussis) vaccine also does not give lifelong immunity, and that may be one reason why there are still outbreaks of the disease. And although pertussis isn't a serious problem for older kids and adults, it can be for infants and young children. Because of this, adolescents and adults now receive a pertussis booster along with the tetanus and diphtheria booster (Tdap) — an important step in controlling this infection.
It's important to keep a record of vaccinations so the doctor knows when your child is due for a booster. Also make sure your child gets the flu vaccine each year, if it isn't in short supply. Having been immunized last year won't protect someone from getting the flu this year because the protection wears off and flu viruses constantly change. That's why the vaccine is updated each year to include the most current strains of the virus.
The flu vaccine reduces the average person's chances of catching the flu by up to 80% during the season. But because the flu vaccine doesn't prevent infection by all of the viruses that can cause flu-like symptoms, getting the vaccine isn't a guarantee that someone won't get sick during the season. But even if someone who's gotten the shot gets the flu, symptoms will usually be fewer and milder.

Are vaccines continuously studied and improved because they're unsafe?

The FDA's Center for Biologics Evaluation and Research is the government agency responsible for regulating vaccines in the United States. Working in conjunction with the CDC and the NIH, they continuously research and monitor vaccine safety and effectiveness.
New vaccines are licensed only after thorough laboratory studies and clinical trials, and safety monitoring continues even after a vaccine has been approved. There have been — and will continue to be — improvements (such as those that have already been made to the DTaP and polio vaccines, for example) that will minimize potential side effects and ensure the best possible safety standards.

Where can I find out more about immunizations?

The CDC's National Immunization Program maintains a website dedicated to helping consumers evaluate information about vaccinations from sources in the media and on the Internet.
And talk with your doctor about which immunizations your child needs — working together, you can help keep your child healthy.

Autism and vaccines

In my infectious disease class, my professor gave us this article about actress, Jenny McCarthy, and her autistic son. The article is by Sam Wang, a professor of molecular biology and neuroscience at Princeton University. He attempts to explain in this article why people still blame autism on vaccines when there is no scientific evidence to back up that claim.

It is important for people to be critical of the information that they are receiving via the media. As it says in the article, people suffer from "source amnesia." We need to be weary of rumors or other information that doesn't site valid scientific evidence.

Autism myth lives on
Why people continue to blame vaccines, despite evidence to the contrary.
By Sam Wang

As the brother of an autistic person and a brain scientist, I have been hoping that the increased focus on autism in the news would lead to a greater public understanding of this disorder. Instead, I am angry that this coverage is spreading dangerous myths.


My sister, Karen, is autistic. In the 1970s, my parents wondered why she behaved so differently. At the time, a prevalent idea was that an emotionally distant mother could somehow prevent a child from understanding emotions or relating normally to others. Our parents had a simpler idea, that they might have hurt Karen's head during a bath.

Both these ideas are wrong. Autism is a neurological disorder, and its signs appear by the age of 1 or even earlier. It is highly inheritable. In identical twins where one is autistic, the chance that both are autistic is greater than 50-50. Even non-identical twins and siblings are at increased risk. In short, I dodged a genetic bullet. Now I worry about my daughter.


A link that isn't there

Recently, celebrities such as Jenny McCarthy and other activists have taken to the airways to repeat the myth that autism is linked to vaccination. Although peer-reviewed scientific evidence overwhelmingly opposes their views, they have attracted attention. In a recent discussion on Larry King Live, three pediatricians invited to make the case for science were no match for McCarthy's star power. Situations like this could mistakenly persuade parents to leave their children unvaccinated and vulnerable to contagious diseases.


Speculation about a vaccine-autism link began with a 1998 uncontrolled study of a few autistic children. But the conclusions were later retracted. Subsequent speculation focused on the compound thimerosal. But removing it from all routine childhood vaccines in the USA, Denmark, Sweden and Canada has not decreased autism rates.

What are McCarthy's credentials? She is an actress and comedienne — with an autistic son. Her career took on new life after she wrote a best-selling pregnancy guide. Like all parents of autistic children, she wrestled with the question of what caused his disorder. She recalled that her son was vaccinated about the time his symptoms first appeared. Aha! That's it. Here is an example of her reasoning: "I believe that parents' anecdotal information is science-based information."

How we're wired


Although her concept of evidence is flawed, I don't blame her. The error highlights how our brains are wired to think. Like the authors of the 1998 study, she concluded that two events happening around the same time must be linked. They used the principle that coincidence implies a causal link. But there was no coincidence for her son: He was born in 2002, after thimerosal was removed from vaccines.

The problem is compounded by "source amnesia," in which people are prone to remember a statement without recalling where they heard it or whether the source was reliable. Presidential candidate John McCain might have fallen prey to source amnesia when he repeated the vaccine-autism myth last month. Recollection is more likely when the "fact" fits previously held views; parents might already dislike vaccinations based on their kids' reaction to shots. But when it comes to a complex issue such as autism, such errors of reasoning hinder us from distinguishing real causes from coincidences.


Out of sight of the cameras, increased research funding is spurring efforts to find autism's causes. Scientists are vitally interested in possible environmental influences. But the vaccine story is a dry well. Working on it further wastes valuable time and resources. It's time to dig elsewhere.

As I watch my beautiful 10-month-old daughter grow, I wish that preventing autism were as simple as withholding a few injections. But along with my wife, a physician, I understand the vital importance of vaccination, not only for maintaining our baby's health but also protecting our community from infectious diseases. Our daughter's next shots are in two months.


Sam Wang is an associate professor of molecular biology and neuroscience at Princeton University. He is a co-author of Welcome to Your Brain: Why You Lose Your Car Keys But Never Forget How to Drive and Other Puzzles of Everyday Life.
Posted at 12:15 AM/ET, April 16, 2008
For information about the safety of vaccines, visit this site.

Introduction

I chose the topic of vaccination awareness because I have seen vaccinations in the media spot light providing incorrect information. There is also a lot of information available through newspapers, television and the internet that present the “dangers” of routine vaccinations. While I’m aware of the rare side effects of vaccinations, I feel that some number of the population may be unaware of the reasons we have routine vaccinations, and the numerous benefits that result in immunizing our population. Vaccinations are on the top ten list, created by the Center for Disease Control (CDC), of the greatest public health achievements of the past century. Routine immunizations protect our population as a whole from diseases such as Polio and Measles, which can be crippling and even deadly. I chose this topic because I want to help individuals become aware of the benefits of immunization and the risks of choosing not to. “Not vaccinating your children is a disservice to the community.” Dr. Cole, professor of Public Health, Brigham Young University.

For more information visit the CDC or WHO websites.